Cortisol Manager by Integrative Therapeutics

Cortisol Manager by Integrative Therapeutics

Code: 501-70453

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Product Description

Stress reducing sleep aid*

Reduces cortisol levels for all-day stress reduction and restful sleep*

Key Benefits:
  • Reduces Stress Fast - Study showed a 60% reduction in saliva cortisol levels in just 24hrs.
  • Promotes relaxation and supports a healthy sleep cycle without the use of habit forming ingredients.*
  • Increases the ability to fall asleep, stay asleep, and will not cause morning grogginess.*
Why a natural sleep aid that manages stress?* Because a good day starts with a good night.* A sound night's sleep leads to an increase in daytime alertness, reaction time, and a positive mood.*

Sufficient sleep also gives you the energy to complete your daily activities.* Everyday stressors cause stress hormones in the body to become elevated. Specific herbs have been clinically shown to reduce stress hormone levels and support the body's relaxation response.*

Why use Cortisol Manager It reduces stress - fast!* Cortisol is a hormone activated by stress. A 28-day pilot study found that Cortisol Manager significantly reduced stress during the course of the study.* In a subgroup tested for salivary cortisol levels, -a drop of more than 60% was observed after the first dose, and averaged 75-83% reduction at study's end.**

It increases the ability to fall asleep and stay asleep - without morning grogginess - while providing all-day stress reduction.* Cortisol Manager™ combines proprietary stress-reducing ingredient and cortisol-lowering botanical blends to help reduce stress and relieve occasional sleeplessness.*

Recommendations for use: For adults, take 1 tablet before bedtime or as recommended by your healthcare practitioner. Increase to 2 tablets during times of high stress. Safe for use every night.

Serving Size: 1 TabletAmount/Serving%DV
Total Carbohydrate <1g <1%**

Sodium 5mg <1%**

Stress-Reducing Proprietary Blend:
ashwagandha (Withania somnifera) (Sensoril® brand) root and leaf extract and L-theanine (Suntheanine® brand)
250mg *

Cortisol-Reducing Proprietary Blend:
magnolia (Magnolia officinalis) bark extract standardized to contain 2% honokiol and 1% magnolol and epimedium (Epimedium koreanum) aerial part extract
225mg *

Phosphatidylserine 50mg *

Other Ingredients: dextrose, cellulose, modified cellulose gum, modified cellulose, magnesium stearate, stearic acid, titanium dioxide color, soy lecithin, vegetable glycerin, and carnauba wax.

Available in 2 Sizes: 30 Tabs and 90 Tabs.

Product Specific Allergen Info:

This product does not contain:
  • artificial flavoring
  • corn
  • dairy products
  • gluten
  • ingredients of animal origin
  • preservatives
  • wheat
  • yeast
All colors used are from natural sources.

How Does It Work? - Cortisol Manager TM Study

The effectiveness of Cortisol Manager dietary supplement was examined in a preliminary, open-label study involving 21 volunteers.6 The combination was taken each night, and results were assessed using salivary cortisol measurements as well as self-assessment questionnaires.

According to the Zung Anxiety Self-Assessment, Cortisol Manager produced a statistically significant reduction in stress over the course of the 28-day study.* After 2 weeks scores reduced from from a baseline of 39.8 to 35.5 (p=0.04); after 4 weeks from 39.8 to 32.7 (p=0.005). Additionally, the participant survey revealed that:
  • 71% of participants felt more relaxed during the day*
  • 71% experienced improved sleep*
  • 64% achieved deeper sleep, while 57% felt they fell asleep more easily*
  • 57% felt their stress level was reduced*
  • 57% felt they were better able to handle stressful situations*
Salivary cortisol levels were measured in a subset of 7 participants at baseline (for two days- rest day and work day) and weekly throughout the 28-day study after product intake commenced. Saliva samples were collected 5 separate times on each collection day. Data were analyzed by calculating the difference between cortisol levels for each day and hour of testing vs. the respective baseline hour cortisol level determined at the beginning of the study. Differences between a given test day's cortisol level and its respective hourly baseline value were calculated for each sample collection time. The total cumulative difference for each sample collection time of each test day was calculated. From this an average difference for the sample collection time was calculated. Finally a "grand average" or "pooled difference" was calculated for the combined test subject data for each sample collection time for all days combined. Based on these data, use of Cortisol Manager decreased salivary cortisol level in relation to baseline at all five sampling times throughout the day. The effect was noted on the first measurements after supplementation began and persisted on a consistent basis throughout the entire study duration. Salivary cortisol levels decreased by more than 60% after the first dose of Cortisol Manager and averaged between -75% and -83% for the total pooled subject data.

No side effects were noted, and the formula was well-tolerated by participants.6

The following chart summarizes the benefits of each of the ingredients in Cortisol Manager:

Ashwagandha (Withania somnifera) Several studies have shown that ashwagandha enhances energy levels and stress resistance.*7ǀ Animal studies show the herb: reduces levels of corticosterone, a stress hormone closely related to cortisol; enhances mood;*9 and helps promote healthy immune system function by increasing red and white blood cell counts and platelet counts.*10
L-Theanine L-theanine is an amino acid known to promote relaxation and stress reduction by inducing muscle relaxation, and reducing occasional anxiety.* L-theanine increases the activity of alpha brain waves � the type associated with increased feelings of relaxation.*11 It also increases the concentration of certain neurotransmitters, including serotonin and dopamine, which promote muscle relaxation and provide relief for occasional sleeplessness. *12ᄽ
Magnolia (Magnolia officinalis) Magnolol and honokiol extracts, derived from magnolia, have promoted relaxations in animal studies.*14�16 In a randomized, placebo controlled study supplementation with a combination of extracts of magnolia and phellodendron resulted in a decrease in transitory anxiety.17
Epimedium (Epimedium koreanum) Flavonoids in Epimedium koreanum has been shown in animals to support a healthy response to stress by the hypothalamic-pituitary-adrenal axis.*18
Phosphatidylserine Extracted from soy lecithin, phosphatidylserine has been clinically shown to significantly reduce serum adrenocorticotropin (ACTH) and cortisol levels and salivary cortisol levels following mental stress.*19 It also reduces plasma levels of epinephrine, norepinephrine, ACTH and cortisol after exposure to physical stress.*20 This phospholipid is a critical structural component of neuronal cells and helps promote a positive mood, by decreasing feelings of stress.*21

Conclusion: Cortisol ManagerTM dietary supplement has been shown to promote stress-relief and quality sleep by balancing levels of cortisol, the stress hormone.* This safe and natural formulation promotes relaxation with no habit-forming ingredients and no morning grogginess.* Cortisol Manager supports healthy cortisol levels, which in turn can help reduce stress, relieve occasional sleeplessness and fatigue, and optimize immune system and neurological function.*

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